Transforming the world’s knowledge from silos to systems

The first systems model of
the world —
powered
by AI

The biggest challenges we face in the world — from health to climate, migration to income inequality — are systems, yet the knowledge we need to address those challenges is siloed.

We believe that it is time to evolve the way we organize the world’s knowledge: from silos
to systems.

So we created System.

System Graph

The first quantitative model of the world as one interconnected system, powered by AI

The system of cognitive dysfunction

The changing relationship between climate and health

The system of cognitive dysfunction

The system of cognitive dysfunction

The system of cognitive dysfunction

System Graph

Constantly evolving with the latest scientific evidence

1
Findings

224 added today

No change

1
Relationships

3 added today

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1
Concepts

224 added today

No change

Surfaced by the System Graph and extracted from verified sources including peer-reviewed studies and expert-curated databases

As at 8:01am EST on 8/19/24

Systems in the News

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System  Health

Contextualize every health decision

"In our AI4HealthyCities initiative, we aim to identify and address the key drivers of cardiovascular health to improve outcomes and inequities. System helps us to quickly synthesize vast amounts of published insights and understand and quantify relationships between determinants and outcomes. In combination with local data, this provides vital information to develop population health roadmaps.”

Peter Speyer
Head of Data & Analytics
The Novartis Foundation

"In our AI4HealthyCities initiative, we aim to identify and address the key drivers of cardiovascular health to improve outcomes and inequities. System helps us to quickly synthesize vast amounts of published insights and understand and quantify relationships between determinants and outcomes. In combination with local data, this provides vital information to develop population health roadmaps.”

Peter Speyer
Head of Data & Analytics
The Novartis Foundation
Read the case study

“A detailed assessment was conducted by a clinical team and ranked to evaluate the quality, relevance, and utility of the citations. A key advantage of System lies in its flexibility and robust tooling which enables nuanced customization based on specific needs.”

Julian Baldwin, Rebecca Hyde, Christina Dinh
Atropos Health
Read the case study

Systems Thinking

Design

Release Notes

Tech

Press & Events

Announcements

Mar 10, 2026

Context Matters: Synthesize API Now Integrates with EHRs for Full Clinical Context

Chethan Gangireddy, M.D., Patrick Wedlock, Eugenie Dulout

In healthcare, context matters. System’s Synthesize API is now designed to solve the context problem for clinical queries.

Read more..
Source: 

Dec 16, 2025

System Awarded $6.5M Program-Related Investment from Wellcome

System, a Public Benefit Corporation developing a systems-based approach to organize the world's data and knowledge, announced today it has been awarded a $6.5M investment from Wellcome

Read more..
Source: 

Dec 11, 2025

System Synthesize Scores 100% on United States Medical Licensing Examination (USMLE)

Chethan Gangireddy, M.D., Eugenie Dulout

Synthesize reached a major milestone, achieving 100% accuracy on the USMLE Step 1, Step 2 CK, and Step 3

Read more..
Source: 

Mar 10, 2026

Context Matters: Synthesize API Now Integrates with EHRs for Full Clinical Context

Chethan Gangireddy, M.D., Patrick Wedlock, Eugenie Dulout

In healthcare, context matters. System’s Synthesize API is now designed to solve the context problem for clinical queries.

Read more..
Source: 

Tech

Dec 16, 2025

System Awarded $6.5M Program-Related Investment from Wellcome

System, a Public Benefit Corporation developing a systems-based approach to organize the world's data and knowledge, announced today it has been awarded a $6.5M investment from Wellcome

Read more..
Source: 

Announcements

Dec 11, 2025

System Synthesize Scores 100% on United States Medical Licensing Examination (USMLE)

Chethan Gangireddy, M.D., Eugenie Dulout

Synthesize reached a major milestone, achieving 100% accuracy on the USMLE Step 1, Step 2 CK, and Step 3

Read more..
Source: 

Tech