The first systems model of the world —powered by AI

The first systems model of
the world —
powered
by AI

The biggest challenges we face in the world — from health to climate, migration to income inequality — are systems, yet the knowledge we need to address those challenges is siloed.

We believe that it is time to evolve the way we organize the world’s knowledge: from silos to systems.

So we created System.

The system of cognitive dysfunction

The changing relationship between climate and health

The system of cognitive dysfunction

The system of cognitive dysfunction

The system of cognitive dysfunction

System Graph

The first quantitative model of the world as one interconnected system

1
findings

224 added today

No change

1
concepts

224 added today

No change

1
relationships

3 added today

No change

Surfaced by the System Graph and extracted from verified sources including peer-reviewed studies and expert-curated databases

As of 8:01am EST on 8/19/24

System API

Build your own apps and models with the System API

"In our AI4HealthyCities initiative, we aim to identify and address the key drivers of cardiovascular health to improve outcomes and inequities. System helps us to quickly synthesize vast amounts of published insights and understand and quantify relationships between determinants and outcomes. In combination with local data, this provides vital information to develop population health roadmaps.”

Peter Speyer
Head of Data & Analytics
The Novartis Foundation

"In our AI4HealthyCities initiative, we aim to identify and address the key drivers of cardiovascular health to improve outcomes and inequities. System helps us to quickly synthesize vast amounts of published insights and understand and quantify relationships between determinants and outcomes. In combination with local data, this provides vital information to develop population health roadmaps.”

Peter Speyer
Head of Data & Analytics
The Novartis Foundation
Read the case study

“A detailed assessment was conducted by a clinical team and ranked to evaluate the quality, relevance, and utility of the citations. A key advantage of System lies in its flexibility and robust tooling which enables nuanced customization based on specific needs.”

Julian Baldwin, Rebecca Hyde, Christina Dinh
Atropos Health
Read the case study

Case Studies

Systems Thinking

Global Issues

Design

Release Notes

Tech

Press & Events

Announcements

Systems IRL

Dec 16, 2025

System Awarded $6.5M Program-Related Investment from Wellcome

System, a Public Benefit Corporation developing a systems-based approach to organize the world's data and knowledge, announced today it has been awarded a $6.5M investment from Wellcome

Read more..
Source: 

Dec 11, 2025

System Synthesize Scores 100% on United States Medical Licensing Examination (USMLE)

Chethan Gangireddy, M.D., Eugenie Dulout

Synthesize reached a major milestone, achieving 100% accuracy on the USMLE Step 1, Step 2 CK, and Step 3

Read more..
Source: 

Oct 2, 2025

System’s Evidence Synthesis Leads in Accuracy

Patrick Wedlock

A blind study that asked clinicians to provide real-world clinical questions and score the accuracy of responses generated by System's Synthesize API

Read more..
Source: