System API

Knowledge infrastructure for research and development

Whether you're training a model, building a research tool, enhancing your application's intelligence, or powering advanced analytics, our API is designed to give you the full power of the System Graph.

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Comprehensive coverage

The API gives you access to a wide array of data sources that are integrated into a cohesive graph. See our corpus of source material here.

Always up to date

The System Graph is updated daily, ensuring that data lag isn’t an issue. Your applications and models will always be using the most up-to-date data.

Scalable and reliable

The API is built on a scalable architecture that can handle high volumes of requests while maintaining reliability and performance.

Graph traversal

Identify the factors directly affecting or affected by any node, investigate potential mediators, and explore multi-hop pathways.

Case Study

How the Novartis Foundation uncovered the system of cardiovascular disease

{
    "nodes": [
        {
            "id": "UBLYDhO7ul",
            "label": "humidity",
            "category": "Environmental - Other environmental factors",
            "roles": [
                "Determinant",
                "Outcome"
            ]
        },
        {
            "id": "XIeA1ck0Rl",
            "label": "dengue fever",
            "category": "Biomedical - Diseases & disorders",
            "roles": [
                "Determinant",
                "Outcome",
                "Agent"
            ]
        }
        
    ],
    "links": [
        {
            "source": "UBLYDhO7ul",
            "target": "XIeA1ck0Rl",
            "last_published": "2023-09-01T00:00:00",
            "median_effect_size": 0.23889982038220456,
            "num_studies": 15,
            "highest_cited": 6,
            "num_significant_findings": 11,
            "num_findings": 17
        }
        
    ]
}

Evidence synthesis

Generates an accurate, comprehensive, transparent, and up-to-date research synthesis, powered by the System Graph and advanced GraphRAG techniques.

Research

System vs GPT-4: A More Accurate and Comprehensive Research Assistant

Research

Keeping Pace with Biomedical Breakthroughs: The Daily Influx of New Research Insights

{
    "summaries": [
        {
            "synthesis_query": "effect of climate on mental health",
            "theme": "Overview",
            "summary": "Climate has a profound impact on mental health, with various factors influencing the rates of mental health issues and emergencies. Heat waves are consistently linked to increases in emergency room visits and hospital admissions for mood disorders, highlighting how high temperatures can exacerbate mental health crises [1][2]. Furthermore, diurnal temperature range has been shown to correlate with higher emergency admissions for schizophrenia, indicating that fluctuations in temperature may play a critical role in mental health outcomes [3]. Extreme heat is associated..."
        },
        {
            "theme": "Climate Factors",
            "summary": "Research has explored various climate factors and their relationship with mental health outcomes. One study evaluated the association between rising daily maximum temperatures and mood, revealing that this increase is associated with no change in the rate of bad daily mood [17]..."
        }
    ]
}

Research findings

Retrieve all of the structured findings and metadata contained in the System Graph for a study or set of studies.

{
    "study": {
        "id": "e588Cv02Q8",
        "doi": "10.1161/01.cir.0000161822.83163.b6",
        "title": "Prospective study of body mass index and risk of stroke in apparently healthy women.",
        "authors": [
            {
                "full_name": "Tobias Kurth",
                "orcid": "0000-0001-7169-2620",
                "openalex_id": "A5044562854"
                ...
        ],
        "journal": "Circulation",
        "publish_date": "2005-04-19",
        "population": "39,053 women participating in the Women's Health Study.",
        ...
    },   
    "id": "Pt-8CuZZhv",
    "finding_type": "statistical",
    "summary": "Body mass index is associated with a 50.0% increase in the likelihood of reaching total stroke.",
    "variable_1": {
        "id": "7F4chGnw6A",
        "name": "Body mass index",
        ...
    },
    "variable_2": {
        "id": "ZiQ3ypeQ6F",
        "name": "total stroke",
        ...
    },
    "statistic_type": "hazard_ratio",
    "statistic_value": 1.5,
    "effect_size": 0.31613984780380244,
    "ci_upper": 1.94,
    "ci_lower": 1.16,
    "p_value": null
}

Build your own apps and models with the System API

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System API

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System API

Knowledge infrastructure for research and development

Graph traversal

Evidence synthesis

Research findings

Build your own apps and models with the System API